Science

THE SCIENCE

Clinical research findings are consistent in showing how certain plant extracts can enhance protection against routine sun exposure, and how they may also help reverse the cumulative effects of photoaging. Decades of research provides persuasive evidence that the proper use of these plant extracts may significantly reduce not only your skin cancer risk, but your overall photoaging risk.

At Duette we have curated a scientifically substantiated proprietary complex of plant extracts, vitamins and minerals that have shown significant groundbreaking effects in their ability in preventing and even reversing specific signs of UV induced sun damage such as wrinkle formation, dehydration and hyperpigmentation ultimately restoring a healthier more resilient appearance to the skin from the inside out.

WHAT IS

photoaging?

Skin is a major safeguard tissue in humans. As biological barrier function is deteriorated by several kinds of stresses, Reactive Oxygen Species (ROS) remains the most detrimental to cutaneous tissue. ROS is defined as “A type of unstable molecule that contains oxygen and easily reacts with various molecules”. Unfortunately, over exposure to UVA/UVB Radiation promotes ROS.

UVB is erythematogenic, carcinogenic, induces photoaging and mutagenic, causing damage to nucleic acids, such as RNA and DNA. UVA on the other hand, is also mildly erythematogenic, promoting ROS (Reactive Oxygen Species) accumulation. ROS also induces direct cell damage, carcinogenesis and primarily contributes to the unwanted signs and symptoms of photoaging. A Broad Spectrum SPF is clearly necessary, However, topical barrier sunscreen methods cannot stop the lower- energy UV photons that cause photoaging.

WHAT CAUSES

Accelerated Skin Aging?

These photons do not cause erythema, but they can induce immunosupression as well as mutations in the DNA of most exposed skin cells of the epidermis and superficial dermis.

These effects are amplified by the increased oxidative damage that results from the energy transfer of these photons to destroy naturally-occurring photoprotective molecules in the skin, as well as producing reactive oxygen species (ROS) throughout the body. The consequences of increased oxidation include extracellular matrix (e.g. collagen) deterioration, cellular apoptosis, plasma membrane destruction, direct DNA damage and increased mutagenesis.*

- The Open Dermatology Journal, 2011, 5, 6-14

Current Trends in Photoprotection - A New Generation of Oral Photoprotectors

HOW DOES

The Duette Prevent and Protect?

Micronutrients can act as UV absorbers, as antioxidants, and can modulate signaling pathways elicited upon UV exposure.

The protective actions primarily driven by DUETTE’s proprietary complex results in the culmination and combination of the most potent antioxidant, phenolic and caretenoid compounds, results in increased protection and control of cutaneous responses to ultraviolet-induced erythema, the interception of inflammatory mechanisms, and the promotion of other cytotoxic responses.